IN SILICO STUDY OF CHEMICAL COMPOUNDS FROM ARECA NUT (ARECA CATECHU L.) ON GABAA RECEPTOR AS ANTI-INSOMNIA CANDIDATES

Objective: In silico study of chemical compounds from areca nut (Areca catechu) on GABAA receptor as anti-insomnia candidates. Methods: Prediction and molecular docking with receptors to find out which are most likely be therapy Results: Molecular AutoDock Vina ADMET prediction via PreADMET website. ADME predictions show that there is one potential compound called syringic acid has the amino residues in common native ligand standard drug compared other compounds, well producing free energy (ΔG) inhibition constants (Ki) lower than ligand. Syringic also a weak bond plasma proteins. However, parameters toxicity, exhibits carcinogenic mutagenic properties. Conclusion: Based results obtained best can used candidate for drugs, namely acid.